Investigator: Dr. Sebastian Arnold

Institution: University of Freiburg

Country: Germany

Project: Defining and interfering with physiological control mechanisms for TBXT during embryonic cell-lineage specification

Award: $250-290K

Description: This project focuses on the role of TBXT (brachyury), a protein crucial for the growth of chordoma tumors. By studying how this protein behaves during embryonic development, researchers hope to better understand its function in chordoma. They aim to identify specific genetic and molecular signals that control TBXT’s activity, which could reveal ways to block its function in tumor cells. The ultimate goal of this project is to identify new therapeutic strategies that target TBXT, providing a potential path to more effective treatments for chordoma patients.